Title
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Chromatographic profiling and identification of two new iridoid- indole alkaloids by UPLC-MS and HPLC-SPE-NMR analysis of an antimalarial extract from **Nauclea pobeguinii**
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Author
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Abstract
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The total 80% EtOH extract of stem bark of Nauclea pobeguinii (Rubiaceae), which is active against uncomplicated falciparum malaria as shown in previous clinical studies, was analysed by means of UPLC-MS and HPLC-SPE-NMR. Apart from the main constituent, strictosamide, a series of minor constituents was identified, including two new iridoid-indole alkaloids, i.e. naucleidinic acid and 19-O-methyl-3,14-dihydroangustoline, together with 8 known iridoid-indole alkaloids, i.e. naucleidinal, magniflorine, naucleofficine D, two diastereoisomers of 3,14-dihydroangustoline, strictosidine, desoxycordifoline, 3 alpha,5 alpha-tetrahydrodeoxycordifoline lactam, and a phenol glycoside 3,4,5-trimethoxyphenol beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside (kelampayoside A). (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved. |
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Language
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English
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Source (journal)
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Phytochemistry letters
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Publication
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2012
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ISSN
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1874-3900
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DOI
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10.1016/J.PHYTOL.2012.02.010
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Volume/pages
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5
:2
(2012)
, p. 316-319
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ISI
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000303663600022
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Full text (Publisher's DOI)
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Full text (publisher's version - intranet only)
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