Title
Chromatographic profiling and identification of two new iridoid- indole alkaloids by UPLC-MS and HPLC-SPE-NMR analysis of an antimalarial extract from **Nauclea pobeguinii**Chromatographic profiling and identification of two new iridoid- indole alkaloids by UPLC-MS and HPLC-SPE-NMR analysis of an antimalarial extract from **Nauclea pobeguinii**
Author
Faculty/Department
Faculty of Sciences. Chemistry
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences. Pharmacy
Research group
Biomolecular & Analytical Mass Spectrometry (BAMS)
Natural Products and Food - Research and Analysis (NatuRA)
Publication type
article
Publication
Subject
Chemistry
Biology
Source (journal)
Phytochemistry letters
Volume/pages
5(2012):2, p. 316-319
ISSN
1874-3900
ISI
000303663600022
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The total 80% EtOH extract of stem bark of Nauclea pobeguinii (Rubiaceae), which is active against uncomplicated falciparum malaria as shown in previous clinical studies, was analysed by means of UPLC-MS and HPLC-SPE-NMR. Apart from the main constituent, strictosamide, a series of minor constituents was identified, including two new iridoid-indole alkaloids, i.e. naucleidinic acid and 19-O-methyl-3,14-dihydroangustoline, together with 8 known iridoid-indole alkaloids, i.e. naucleidinal, magniflorine, naucleofficine D, two diastereoisomers of 3,14-dihydroangustoline, strictosidine, desoxycordifoline, 3 alpha,5 alpha-tetrahydrodeoxycordifoline lactam, and a phenol glycoside 3,4,5-trimethoxyphenol beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside (kelampayoside A). (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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