Title
Self-monitoring as a familial vulnerability marker for psychosis : an analysis of patients, unaffected siblings and healthy controlsSelf-monitoring as a familial vulnerability marker for psychosis : an analysis of patients, unaffected siblings and healthy controls
Author
Faculty/Department
Faculty of Social Sciences. Political Sciences
Research group
Citizenship, Equality & Diversity (CED)
Publication type
article
Publication
London,
Subject
Psychology
Human medicine
Source (journal)
Psychological medicine. - London, 1970, currens
Volume/pages
42(2012):2, p. 235-245
ISSN
0033-2917
ISI
000299887700002
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background. Alterations in self-monitoring have been reported in patients with psychotic disorders, but it remains unclear to what degree they represent true indicators of familial vulnerability for psychosis. Method. An error-correction action-monitoring task was used to examine self-monitoring in 42 patients with schizophrenia, 32 of their unaffected siblings and 41 healthy controls. Results. Significant between-group differences in self-monitoring accuracy were found (chi(2) = 29.3, p < 0.0001), patients performing worst and unaffected siblings performing at an intermediate level compared to controls (all between-group differences p < 0.05). In the combined group of healthy controls and unaffected siblings, detection accuracy was associated with positive schizotypy as measured by the Structured Interview for Schizotypy - Revised (SIS-R) (beta = -0.16, S.E. = 0.07, p = 0.026), but not with negative schizotypy (beta = -0.05, S.E. = 0.12, p = 0.694). In patients, psychotic symptoms were not robustly associated with detection accuracy (beta = -0.01, S.E. = 0.01, p = 0.094), although stratified analysis revealed suggestive evidence for association in patients not currently using antipsychotic medication (beta = -0.03, S.E. = 0.01, p = 0.052), whereas no association was found in patients on antipsychotic medication (beta = -0.01, S.E. = 0.01, p = 0.426). A similar pattern of associations was found for negative symptoms. Conclusions. Alterations in self-monitoring may be associated with familial risk and expression of psychosis. The association between psychotic symptoms and self-monitoring in patients may be affected by antipsychotic medication, which may explain previous inconsistencies in the literature. Received 31 January 2011; Revised 3 June 2011; Accepted 6 June 2011; First published online 7 July 2011
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