Title
The role of the bone marrow microenvironment in multiple myeloma The role of the bone marrow microenvironment in multiple myeloma
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Murcia ,
Subject
Biology
Human medicine
Source (journal)
Histology and histopathology. - Murcia
Volume/pages
20(2005) :4 , p. 1227-1250
ISSN
0213-3911
ISI
000232715000023
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Multiple myeloma (MM) is a malignant disease that results from an excess of monotypic plasma cells in the bone marrow (BM). This malignancy is characterised by complex karyotypic aberrancies. In 60% of all MM there are recurrent primary translocations involving the heavy chain gene locus. The MM cells strongly interact with the BM microenvironment, which is composed of endothelial cells, stromal cells, osteoclasts, osteoblasts, immune cells, fat cells and the extracellular matrix. This interaction is responsible for the specific homing in the BM, the proliferation and survival of the MM cells, the resistance of MM cells to chemotherapy, the development of osteolysis, immunodeficiency and anaemia. New therapeutic agents target both the MM, as well as the interaction MM cell - BM microenviroment.
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