Publication
Title
Clinical manifestations of systemic paraphenylene diamine intoxication
Author
Abstract
Background: To report clinical symptoms and outcome of systemic paraphenylene diamine (PPD) intoxication. Methods: Our study was retrospective. It was conducted over 6 yrs (1994-2000) in die medical intensive care unit (ICU) of a university hospital and it concerned 19 patients hospitalized for systemic PPD intoxication. Results: The mean age (+/- SD) was 27.9 +/- 16.8 yrs, the sex ratio was about 0.58 and the Simplified Acute Physiology Score (SAPS II) was 30 +/- 27. At admission, clinical symptoms were dominated by cervicofacial edema (79%), chocolate brown colored urine (74%), upper airway tract edema (68.4%), oliguria (36.8%), muscular edema (26.3%) and shock (26.3%). The biological results were dominated by rhabdomyolysis (100%), metabolic acidosis (100%), acute renal failure (ARF) (47.4%) and hyperkalemia (26.3%) (biological disturbances were more pronounced in patients with ARF). The therapies used were gastric lavage (100%), fluid infusion (100%), mechanical ventilation (84.2%), alcalinization (80%), corticosteroids (84.2%), vasopressors (26.3%) and renal replacement therapy (26.3%). The intoxication evolution was marked by the death of six patients (31.6%); five of them had developed ARE The mechanical ventilation duration and the ICU stay were both more prolonged in patients who developed ARE Conclusions: Clinical manifestations of systemic PPD intoxication were associated with respiratory, muscular, renal and hemodynamic syndromes. ARF occurrence testifies to the severity of the intoxication.
Language
English
Source (journal)
Journal of nephrology. - Milano
Publication
Milano : 2005
ISSN
1121-8428
Volume/pages
18:3(2005), p. 308-311
ISI
000230584300015
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 12.07.2012
Last edited 11.12.2017
To cite this reference