Title
Traditional systemic treatments have not fully met the needs of psoriasis patients : results from a national survey Traditional systemic treatments have not fully met the needs of psoriasis patients : results from a national survey
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Saint Louis, Mo ,
Subject
Human medicine
Source (journal)
Journal of the American Academy of Dermatology. - Saint Louis, Mo
Volume/pages
52(2005) :3 , p. 434-444
ISSN
0190-9622
ISI
000227630700007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Background: Many psoriasis patients are dissitisfied with current therapies. However, patient-centered levels of satisfaction with individual treatments have not been well described . Objective: To assess patients' satisfaction with 4 systemic treatment options available before 2002. Methods: We useddata from a recent national survey. Psoriasis patients were randomly recruited from the general US population, members of the Psoriasis Foundation, and persons who contacted the Psoriasis Foundation but did not join. The interview included questions about use and satisfaction with specific Psoriasis therapy. Results: of 1197 psoriasis patients interviewed, 311 (26%) indicated current or past use of methotrexate, psoralen plus ultraviolet A (PUVA), cyclosporin, and/or acitretin (users). Compared with theose who had never used any of these systematic therapies, users reported more extensive disease (adjusted odds ratio [OR] = 2.90, 95% confidence interval [Cl] = 1.84-4.49) and higher Psoriasis Disability Index scores (category V : adjusted OR = 2.31, 95% Cl = 1.22-4.36). After adjusting for these variables, more than one third of patients were dissatisfied with each therapy, except for PUVA (14%). Patients were most satisfied with methotrexate and PUVA. However, less than 40% of the users indicated they were very satisfied with any of the 4 therapies assessed. Only 10% of persons who ever used cyclosporin were currently using it. In a paired analysis cyclosporin users were significantly less satisfied with cyclosporin than with other therapies (P = .01). Conclusion: For most patients, none of the 4 systemic therapies widely utilized in 2002 for psoriasis were highly satisfactory. If we are to learn whether new treatments satisfy patients' needs, long term , prospective, comparative studies of heterogenous patient populations that include patients assessments are needed.
E-info
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