Title
Molecular diagnostic tools in Creutzfeldt-Jakob disease and other prion disorders Molecular diagnostic tools in Creutzfeldt-Jakob disease and other prion disorders
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Subject
Human medicine
Source (journal)
Expert review of molecular diagnostics
Volume/pages
4(2004) :3 , p. 351-359
ISSN
1473-7159
ISI
000221285900009
Carrier
E
Target language
English (eng)
Affiliation
University of Antwerp
Abstract
Clinical criteria and cerebrospinal fluid biomarkers for the diagnosis of human prion diseases (sporadic, iatrogenic or variant Creutzfeldt-Jakob disease and genetic inherited transmissible spongiform encephalopathies) are now widely available and show a sensitivity and specificity of approximately 98%. Final diagnosis of prion diseases is obtained by post-mortem examination upon identification of the pathological conformer of the prion protein (PrP(Sc)) in the brain. Several diagnostic kits are now available that facilitate the Immunochemical measurement of PrP(Sc). Several new molecular diagnostic techniques, aimed at increasing the sensitivity and specificity of PrP(Sc) detection and at identifying markers of disease other than PrP(Sc), are the subject of ongoing studies. The aim of these studies is to develop preclinical screening tests for the identification of infected but still healthy individuals. These tests are also essential to investigate the safety of blood or blood-derived products and to ensure meat safety in European countries.
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