Publication
Title
Systematic overview of the pharmacological management of postherpetic neuralgia - An evaluation of the clinical value of critically selected drug treatments based on efficacy and safety outcomes from randomized controlled studies
Author
Abstract
Objective: This study systematically reviews current evidence on drug treatments commonly used in postherpetic neuralgia. Methods: Randomized controlled trials were critically selected using predefined search criteria. Efficacy was evaluated as percentage of improvement in pain intensity between baseline and endpoint, tolerability by number of study discontinuations because of adverse events and incidence of adverse events. Results: Currently published trials enrolled different patient populations and small patient numbers. The great variability in doses, titration schemes, designs and washout periods together with other design flaws made comparison between different studies scientifically impossible. Conclusions: There is a real need for well-performed clinical trials with standardization in design and reporting. Development of adequate and validated questionnaires for evaluation and comparison of efficacy and safety of treatments is also needed. Based on the evaluation of individual studies, it is concluded that only gabapentin is studied in large (over 200 patients), placebo-controlled studies showing good efficacy and safety. Copyright (C) 2004 S. Karger AG, Basel.
Language
English
Source (journal)
Dermatology. - Basel
Publication
Basel : 2004
ISSN
1018-8665
Volume/pages
208:3(2004), p. 206-216
ISI
000221112100005
Full text (Publisher's DOI)
UAntwerpen
Publication type
Subject
External links
Web of Science
Record
Identification
Creation 12.07.2012
Last edited 17.07.2017