Title
Ultrasound agents may open the blood-brain barrier in rats and aggravate pathologic consequences of experimental head trauma Ultrasound agents may open the blood-brain barrier in rats and aggravate pathologic consequences of experimental head trauma
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Oxford ,
Subject
Human medicine
Source (journal)
Neuropathology. - Oxford
Volume/pages
23(2003) :3 , p. 210-213
ISSN
0919-6544
ISI
000185191100009
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Unilateral intracarotid injection of contrast agents may considerably destabilize the blood - brain barrier in rats. This leads to vasogenic edema in the ipsilateral hemisphere. Mortality and extravasation increased significantly when administration of these ultrasound contrast agents was followed by mild traumatic brain injury. Direct administration to the cerebral circulation is, therefore, indicative for edema-related pathology and may amplify the consequences of experimental neurotrauma.
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