Title
A chronic-constriction injury of the sciatic nerve reduces bilaterally the responsiveness to formalin in rats: A behavioral and hormonal evaluationA chronic-constriction injury of the sciatic nerve reduces bilaterally the responsiveness to formalin in rats: A behavioral and hormonal evaluation
Author
Publication type
article
Publication
Philadelphia :Lippincott williams & wilkins,
Subject
Human medicine
Source (journal)
Anesthesia and analgesia / International Anesthesia Research Society. - Cleveland, Ohio, 1957, currens
Source (book)
2nd International Conference on Mechanisms and Treatment of Neuropathic, Pain, JUN 03-05, 1999, WASHINGTON, D.C.
Volume/pages
97(2003):2, p. 520-525
ISSN
0003-2999
ISI
000184354600039
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Abstract
Application of four loose ligatures to the sciatic nerve of a rat (chronic constriction injury [CCI]) induces clear hypersensitivity to non-noxious stimulation and chemical irritants. However, in this study, an injection of formalin in the hind paw of a rat with CCI-induced mononeuropathy resulted in an ipsilateral decreased flinching and licking or biting behavior in both phases of the formalin testing. The effect was independent of the formalin concentration used. This altered behavior was accompanied with smaller plasma levels of adrenocorticotrope hormone and corticosterone compared with sham and non-operated animals. Formalin injection in the contralateral nonligated hind paw of CCI rats also reduced the licking or biting behavior as compared with sham-operated and non-operated control animals only in the second phase of the formalin test. Thus, CCI reduces the pain reactivity and hypothalamic-pituitary-adrenal-axis activation to ipsilateral and contralateral formalin injection. Further research should investigate whether the decreased pain reactivity by CCI is situated at the peripheral, spinal, or supraspinal level or is result of changes in the stress reactivity and coping strategies.
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