Title
Lack of a modulatory effect of imipramine on glucocorticoid-induced suppression of interferon-gamma and interleukin-10 production in vitro Lack of a modulatory effect of imipramine on glucocorticoid-induced suppression of interferon-gamma and interleukin-10 production in vitro
Author
Publication type
article
Publication
Krakow ,
Subject
Pharmacology. Therapy
Source (journal)
Polish journal of pharmacology / Polish Academy of Sciences. Institute of Pharmacology. - Krakow
Volume/pages
53(2001) :3 , p. 289-294
ISSN
1230-6002
ISI
000169855400010
Carrier
E
Target language
English (eng)
Abstract
Antidepressant drugs have been shown to reverse some changes evoked by glucocorticoids or stress. In the present study we attempted to find out whether imipramine, one of the most frequently used antidepressant drugs, interfered with glucocorticoids, modulating the production of IFN-gamma and IL-10, pro-inflammatory and anti-inflammatory cytokines, respectively. We observed a significant inhibitory effect of hydrocortisone, dexamethasone and the glucocorticoid receptor agonist RU 28362, used at doses of 10(-6) and 10(-5) M, on the production of IFN-gamma and IL-10 by whole blood cells stimulated by mitogens. Imipramine at doses of 10(-6) and 10-5 M did not modulate IFN-gamma or IL-10 production, whereas at a dose of 10(-6) M it increased the production of IL-10 and decreased that of IFN-gamma, those results being statistically insignificant, though. A combination of imipramine and dexamethasone or hydrocortisone at doses of 10(-6) or 10-5 M significantly suppressed the production of IFN-gamma and IL-10, the level of inhibition being similar to that observed for glucocorticoids alone. The classic antidepressant imipramine was not able to modulate the suppressive effect of "stress" doses of hydrocortisone on the production of cytokines.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/59bf6b/7568.pdf
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