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Title
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In new-onset insulin-dependent diabetic patients the presence of anti-thyroid peroxidase antibodies is associated with islet cell autoimmunity and the high risk haplotype HLA DQA1*0301-DQB1*0302
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Author
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Institution/Organisation
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Belgian Diabetes Registry
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Abstract
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| In 157 new onset IDDM (104 men, 53 women, ages 10-39 yr) anti-thyroid peroxidase anti-bodies (anti-TPO) were assayed with a specific immunological test. Values greater than 100 U ml(-1) were considered positive. Seventeen per cent of the patients were positive (32% of the women versus 10% of the men, p < 0.001). Eighty-five per cent of the anti-TPO+ patients have a positive titre of islet-cell antibodies (ICA greater than or equal to 12 JDFU) versus 64% of the anti-TPO-patients (p < 0.05). When patients were subdivided in a young (10-25 yr) and an older age group (26-39 yr) this association was also true for ICA greater than or equal to 50 JDFU and valid for insulin autoantibodies (IAA) at low (greater than or equal to 0.7%) and high risk (greater than or equal to 1.5%) (p < 0.005) in the second group. The median of the TSH concentration was not different between anti-TPO+ and anti-TPO- when the group is considered as a whole. In the anti-TPO+ men (26-39 yr) TSH was however significantly greater (1.55 mu U ml(-1), range 0.74-8.5 versus 1.4 mu U ml(-1), range 0.21-3.5, p < 0.0001) when compared to the anti-TPO-men of the same age group. The haplotype HLA DQA1*0301-DQB1*0302 was more frequent in the anti-TPO+ (39%) than in the anti-TPO- (23%) patients (p < 0.02) for the age group 26-39 yr but not for the age group 10-25 yr. The other diabetes susceptibility haplotype DQA1*0501-DQB1*0201 was less frequent in anti-TPO+ patients. In conclusion we suggest that thyroid auto-immunity must be part of the initial screening of IDDM especially when patients are older at clinical onset of the disease. |
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Language
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English
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Source (journal)
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Diabetic medicine / British Diabetic Association. - Chichester, 1984, currens
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Publication
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Chichester
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Wiley
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1996
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ISSN
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0742-3071
[print]
1464-5491
[online]
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DOI
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10.1002/(SICI)1096-9136(199605)13:5<415::AID-DIA96>3.0.CO;2-X
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Volume/pages
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13
:5
(1996)
, p. 415-419
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ISI
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A1996UM87000005
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Full text (Publisher's DOI)
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