Low bone alkaline-phosphatase : a sensitive, specific marker for adynamic bone-disease in dialysis patients
Faculty of Medicine and Health Sciences
Nieren- und Hochdruckkrankheiten. - München
, p. 380-383
University of Antwerp
Out of all laboratory parameters indicating bone formation bone specific alkaline phosphatase (BAP) is the one suited best for detection of renal low rum over osteopathy because its elimination is independent from renal function. Measurement of different isoenzymes of alkaline phosphatase is possible after separating them by agarose electrophoresis. The normal range has been determined in more than 400 patients on hemodialysis. The often unexpectedly low concentrations of bone specific alkaline phosphatase show a good correlation with osteocalcin and iPTH, respectively. Due to bone biopsies and by means of receiver operator curves an optimal discrimination level has meanwhile been determined for the diagnosis of adynamic bone disease.