Title
Incidence of low-fluorescence a satellite region on chromosome-21 escaping detection of aneuploidy at interphase by fish
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Basel ,
Subject
Biology
Human medicine
Source (journal)
Cytogenetics and cell genetics. - Basel, 1973 - 2001
Volume/pages
68(1995) :3/4 , p. 203-206
ISSN
0301-0171
ISI
A1995PX89000075
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Aneuploidy detection for chromosome 21 by fluorescence in situ hybridization (FISH) to interphase nuclei using a probe specific for the alphoid DNA sequences D21Z1/D13Z1 should be avoided. An extreme heteromorphism, resulting in misdiagnosis if interphase FISH is the only test employed, may be far more frequent (4/101) than expected.
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