Title
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Incidence of low-fluorescence a satellite region on chromosome-21 escaping detection of aneuploidy at interphase by fish
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Author
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Abstract
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Aneuploidy detection for chromosome 21 by fluorescence in situ hybridization (FISH) to interphase nuclei using a probe specific for the alphoid DNA sequences D21Z1/D13Z1 should be avoided. An extreme heteromorphism, resulting in misdiagnosis if interphase FISH is the only test employed, may be far more frequent (4/101) than expected. |
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Language
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English
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Source (journal)
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Cytogenetics and cell genetics. - Basel, 1973 - 2001
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Publication
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Basel
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1995
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ISSN
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0301-0171
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DOI
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10.1159/000133914
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Volume/pages
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68
:3/4
(1995)
, p. 203-206
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ISI
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A1995PX89000075
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Full text (Publisher's DOI)
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