|
Title
|
|
|
|
Expression of c-erbB-2, c-myc, and c-ras oncoproteins, insulin-like growth-factor receptor I, and epidermal growth-factor receptor in ovarian carcinoma
| |
|
Author
|
|
|
|
| |
|
Abstract
|
|
|
|
| Aims-To assess whether the overexpression of five dominant oncogene encoded proteins is crucial to the pathogenesis of ovarian carcinoma and whether this provides any useful prognostic information. Methods-The expression of the insulinlike growth factor 1 receptor (ILGFR 1), epidermal growth factor receptor (EGFR), and the c-erbB-2, c-ras, and c-myc products was studied by multiparameter flow cytometry in 80 patients with epithelial ovarian cancer for whom long term follow up was available. Results-Overexpression of ILGFR 1, EGFR, c-erbB-2, c-ras and c-myc was found in, respectively, nine of 80 (11%), 10 of 80 (12%), 19 of 80 (24%), 16 of 80 (20%) and 28 of 80 (35%) ovarian carcinomas. The levels of expression of ILGFR 1, EGFR, c-erbB-2 and c-ras were significantly higher in the tumours of patients with recurrent or persistent disease after chemotherapy than in the tumours of patients at initial presentation (p < 0.02). Multivariate analysis showed that residual tumour (p < 0.001), FIGO stage (p = 0.002), EGFR overexpression (p = 0.030) and previous chemotherapy (p = 0.034) were independent variables for predicting survival. Conclusions-Overexpression of these oncoproteins only occurs in a small proportion of ovarian carcinomas but may have an important role in the progression of the disease. |
| |
|
Language
|
|
|
|
English
| |
|
Source (journal)
|
|
|
|
Journal of clinical pathology. - London
| |
|
Publication
|
|
|
|
London
:
1994
| |
|
ISSN
|
|
|
|
0021-9746
| |
|
DOI
|
|
|
|
10.1136/JCP.47.10.914
| |
|
Volume/pages
|
|
|
|
47
:10
(1994)
, p. 914-919
| |
|
ISI
|
|
|
|
A1994PN02200008
| |
|
Full text (Publisher's DOI)
|
|
|
|
| |
|
Full text (publisher's version - intranet only)
|
|
|
|
| |
|