Title
Randomized double-blind trial of the safety and efficacy of two gadolinium complexes (Gd-DTPA and Gd-DOTA) Randomized double-blind trial of the safety and efficacy of two gadolinium complexes (Gd-DTPA and Gd-DOTA)
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Publication type
article
Publication
Berlin ,
Subject
Human medicine
Computer. Automation
Source (journal)
Neuroradiology. - Berlin
Volume/pages
36(1994) :1 , p. 27-30
ISSN
0028-3940
ISI
A1994MM55600007
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The main difference between macrocyclic Gd-DOTA and linear Gd-DTPA complexes is the greater stability of the former which theoretically might reduce biological interactions in man. To evaluate the clinical relevance of this property, 300 unselected neurological patients were included in a randomised double-blind comparison involving five European centres, focused mainly on the tolerance of these two contrast media. Clinical tolerance was assessed immediatley after the procedure and 24 h later. Adverse events were found with a similar frequency in the two groups (17.3 % for Gd-DOTA and 19.3 % for Gd-DTPA). Minor neurological symptoms were the most frequent (48.6 %) headache being the most common (29.2 % of adverse events). No difference in efficacy was found.
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