Publication
Title
Randomized double-blind trial of the safety and efficacy of two gadolinium complexes (Gd-DTPA and Gd-DOTA)
Author
Abstract
The main difference between macrocyclic Gd-DOTA and linear Gd-DTPA complexes is the greater stability of the former which theoretically might reduce biological interactions in man. To evaluate the clinical relevance of this property, 300 unselected neurological patients were included in a randomised double-blind comparison involving five European centres, focused mainly on the tolerance of these two contrast media. Clinical tolerance was assessed immediatley after the procedure and 24 h later. Adverse events were found with a similar frequency in the two groups (17.3 % for Gd-DOTA and 19.3 % for Gd-DTPA). Minor neurological symptoms were the most frequent (48.6 %) headache being the most common (29.2 % of adverse events). No difference in efficacy was found.
Language
English
Source (journal)
Neuroradiology. - Berlin
Publication
Berlin : 1994
ISSN
0028-3940
Volume/pages
36:1(1994), p. 27-30
ISI
A1994MM55600007
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 19.07.2012
Last edited 16.06.2017
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