Title
Noninvasive molecular imaging of neuroinflammationNoninvasive molecular imaging of neuroinflammation
Author
Contributor
Van Der Linden, Annemie
Ponsaerts, Peter
Author
Faculty/Department
Faculty of Medicine and Health Sciences
Faculty of Pharmaceutical, Biomedical and Veterinary Sciences . Biomedical Sciences
Research group
Vaccine & Infectious Disease Institute (VAXINFECTIO)
Bio-Imaging lab
Publication type
article
Publication
New York, N.Y.,
Subject
Human medicine
Source (journal)
Journal of cerebral blood flow and metabolism. - New York, N.Y., 1981, currens
Volume/pages
32(2012):7, p. 1393-1415
ISSN
0271-678X
1559-7016
ISI
000305970800021
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous system (CNS) is now recognized to have a constant interplay with the innate and the adaptive immune systems, where resident microglia and infiltrating immune cells from the periphery have important roles. Common diseases of the CNS, such as stroke, multiple sclerosis (MS), and neurodegeneration, elicit a neuroinflammatory response with the goal to limit the extent of the disease and to support repair and regeneration. However, various disease mechanisms lead to neuroinflammation (NI) contributing to the disease process itself. Molecular imaging is the method of choice to try to decipher key aspects of the dynamic interplay of various inducers, sensors, transducers, and effectors of the orchestrated inflammatory response in vivo in animal models and patients. Here, we review the basic principles of NI with emphasis on microglia and common neurologic disease mechanisms, the molecular targets which are being used and explored for imaging, and molecular imaging of NI in frequent neurologic diseases, such as stroke, MS, neurodegeneration, epilepsy, encephalitis, and gliomas.
Full text (open access)
https://repository.uantwerpen.be/docman/irua/cdb4ee/ca29af49.pdf
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