Title
In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter In vivo observation and biophysical interpretation of time-dependent diffusion in human white matter
Author
Faculty/Department
Faculty of Sciences. Physics
Publication type
article
Publication
New York ,
Subject
Human medicine
Computer. Automation
Source (journal)
Neuroimage. - New York
Volume/pages
129(2016) , p. 414-427
ISSN
1053-8119
ISI
000372745300035
Carrier
E
Target language
English (eng)
Full text (Publishers DOI)
Affiliation
University of Antwerp
Abstract
The presence ofmicrometer-level restrictions leads to a decrease of diffusion coefficient with diffusion time. Here we investigate this effect in human white matter in vivo. We focus on a broad range of diffusion times, up to 600 ms, covering diffusion length scales up to about 30 mu m. We perform stimulated echo diffusion tensor imaging on 5 healthy volunteers and observe a relatively weak time-dependence in diffusion transverse to major fiber tracts. Remarkably, we also find notable time-dependence in the longitudinal direction. Comparing models of diffusion in ordered, confined and disordered media, we argue that the time-dependence in both directions can arise due to structural disorder, such as axonal beads in the longitudinal direction, and the random packing geometry of fibers within a bundle in the transverse direction. These time-dependent effects extend beyond a simple picture of Gaussian compartments, and may lead to novel markers that are specific to neuronal fiber geometry at the micrometer scale. (C) 2016 Elsevier Inc. All rights reserved.
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