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Title
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Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR-Ullmann cross-coupling sequence
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Author
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Abstract
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| A 3-step methodology for the synthesis of 1,5-benzothiazepin-4(5H)-one dipeptidomimetics has been elaborated via an Ugi-4CR followed by a S-trityl deprotection and an intramolecular Cu(I)-catalyzed Ullmann condensation with moderate to good yields. In silico and NMR conformational studies showed that the lowest energy conformers stabilize gamma-and beta-turn structures. |
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Language
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English
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Source (journal)
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Organic and biomolecular chemistry. - Cambridge, 2003, currens
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Publication
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Cambridge
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Royal Society of Chemistry
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2018
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ISSN
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1477-0520
[print]
1477-0539
[online]
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DOI
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10.1039/C7OB03094K
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Volume/pages
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16
:8
(2018)
, p. 1242-1246
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ISI
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000429264000003
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Pubmed ID
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29379930
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Full text (Publisher's DOI)
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Full text (open access)
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