Publication
Title
Rapid construction of substituted 3-amino-1,5-benzothiazepin-4(5H)-one dipeptide scaffolds through an Ugi-4CR-Ullmann cross-coupling sequence
Author
Abstract
A 3-step methodology for the synthesis of 1,5-benzothiazepin-4(5H)-one dipeptidomimetics has been elaborated via an Ugi-4CR followed by a S-trityl deprotection and an intramolecular Cu(I)-catalyzed Ullmann condensation with moderate to good yields. In silico and NMR conformational studies showed that the lowest energy conformers stabilize gamma-and beta-turn structures.
Language
English
Source (journal)
Organic and biomolecular chemistry. - Cambridge, 2003, currens
Publication
Cambridge : 2018
ISSN
1477-0520 [print]
1477-0539 [online]
Volume/pages
16 :8 (2018) , p. 1242-1246
ISI
000429264000003
Pubmed ID
29379930
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identification
Creation 04.05.2018
Last edited 20.09.2021
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