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Title
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Analytical performance of a platform for point-of-care CRP testing in adults consulting for lower respiratory tract infection in primary care
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Author
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Institution/Organisation
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GRACE consortium
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Abstract
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| C-reactive protein (CRP) is a biomarker widely used for disease severity assessment and treatment of inflammatory conditions. Point-of-care testing (POCT) devices should ideally be rapid and provide similar results to standard tests done in laboratories. Two thousand nine hundred twenty-two serum samples were obtained from adult patients presenting to primary care with symptoms of lower respiratory infection in a European diagnostic study. The analytic performance of the CRP QuikRead POCT device (Orion Diagnostica) was evaluated by comparing results with a central laboratory method (Dimension Vista, Siemens), with both tests performed in a laboratory setting. For a CRP cut-off concentration of ≥ 30 mg/L, the QuikRead test had a sensitivity of 92.2%, and specificity of 99.4%. The mean difference between the QuikRead and the central lab test was 0.4 mg/L. The slope of the Passing-Bablok regression was 0.94 (95% CI 0.930.95) indicating an underestimation of CRP levels of 6% by QuikRead. CRP estimates obtained from the QuikRead test correlate well with a central laboratory assay and the measurement displays low inter-assay variation. Therefore, the QuikRead test is a good candidate for CRP testing in primary care. |
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Language
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English
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Source (journal)
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European journal of clinical microbiology and infectious diseases. - Wiesbaden
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Publication
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Wiesbaden
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2018
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ISSN
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0934-9723
[print]
1435-4373
[online]
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DOI
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10.1007/S10096-018-3253-3
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Volume/pages
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37
:7
(2018)
, p. 1319-1323
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ISI
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000435950400016
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Pubmed ID
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29744764
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Full text (Publisher's DOI)
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Full text (open access)
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Full text (publisher's version - intranet only)
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