|
Title
|
|
|
|
Analytical performance of a platform for point-of-care CRP testing in adults consulting for lower respiratory tract infection in primary care
|
|
|
Author
|
|
|
|
|
|
|
Institution/Organisation
|
|
|
|
GRACE consortium
|
|
|
Abstract
|
|
|
|
| C-reactive protein (CRP) is a biomarker widely used for disease severity assessment and treatment of inflammatory conditions. Point-of-care testing (POCT) devices should ideally be rapid and provide similar results to standard tests done in laboratories. Two thousand nine hundred twenty-two serum samples were obtained from adult patients presenting to primary care with symptoms of lower respiratory infection in a European diagnostic study. The analytic performance of the CRP QuikRead POCT device (Orion Diagnostica) was evaluated by comparing results with a central laboratory method (Dimension Vista, Siemens), with both tests performed in a laboratory setting. For a CRP cut-off concentration of ≥ 30 mg/L, the QuikRead test had a sensitivity of 92.2%, and specificity of 99.4%. The mean difference between the QuikRead and the central lab test was 0.4 mg/L. The slope of the Passing-Bablok regression was 0.94 (95% CI 0.930.95) indicating an underestimation of CRP levels of 6% by QuikRead. CRP estimates obtained from the QuikRead test correlate well with a central laboratory assay and the measurement displays low inter-assay variation. Therefore, the QuikRead test is a good candidate for CRP testing in primary care. |
|
|
|
Language
|
|
|
|
English
|
|
|
Source (journal)
|
|
|
|
European journal of clinical microbiology and infectious diseases. - Wiesbaden
|
|
|
Publication
|
|
|
|
Wiesbaden
:
2018
|
|
|
ISSN
|
|
|
|
0934-9723
[print]
1435-4373
[online]
|
|
|
Volume/pages
|
|
|
|
37
:7
(2018)
, p. 1319-1323
|
|
|
ISI
|
|
|
|
000435950400016
|
|
|
Pubmed ID
|
|
|
|
29744764
|
|
|
Full text (Publisher's DOI)
|
|
|
|
|
|
|
Full text (open access)
|
|
|
|
|
|
|
Full text (publisher's version - intranet only)
|
|
|
|
|
|