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Localised model-based active controlling of blood flow during chemotherapy to prevent nail toxicity and onycholysis
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| Abstract |
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| Chemotherapy-induced nail toxicity is a widely spread phenomenon. Cooling the patients hands can reduce blood flow to the fingers and consequently reducing the amount of chemical agents reaching the nails. This paper is aiming at developing a model-based controller of the fingers skin temperatures and blood flow to reduce the risk of nail toxicity during chemotherapy. Experiments were conducted to model the dynamic response of the fingers skin temperature and blood flow using an ad hoc experimental device. The device was designed to provide a localised cooling of the fingers. The experiments were performed on a homogeneous test group of 11 middle-aged women. The fingers skin temperatures and blood flow were measured continuously. A second order discrete time transfer function model was suitable (R 2 = 0.91 ± 0.18) in all the cases to model the dynamic responses of the fingers skin temperatures. The model estimation results have shown that the a- and b-parameters were varying among different test subjects and within the same subject. The resulted models were employed in designing a model-based proportional-integral-plus controller. Simulations of the closed-loop systems were performed based on the identified models for each test subject. The simulation results have shown that the designed controller is able to regulate the fingers skin temperatures tightly about the desired level and yet, is still quite simple to implement in practice. Controlled active cooling with an online parameter estimation algorithm and continuous feedback of the patient finger temperatures is a promising solution to reduce nail toxicity during chemotherapy. |
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English
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Journal of medical and biological engineering |
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2019
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39:1(2019), p. 139-150
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000457198100014
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| Full text (Publisher's DOI) |
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| Full text (open access) |
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