Publication
Title
The influence on the oral bioavailability of solubilized and suspended drug in a lipid nanoparticle formulation : in vitro and in vivo evaluation
Author
Abstract
The present study investigated the oral bioavailability of celecoxib when incorporated into solid lipid nano-particles either dissolved or suspended. In vitro drug release in different media, in vivo performance, and in vitro-in vivo correlation were conducted. The results revealed that the compound was successfully encapsulated into the nanocarriers with good physicochemical properties for oral administration. The in vitro release profiles followed the Weibull model, with significant differences between the formulations containing the solubilized and the suspended compound. Furthermore, in vitro release data could be used to rank the observed in vivo bioavail-ability. The relative bioavailability of celecoxib from the solid lipid nanoparticles was 2.5-and 1.8-fold higher for the drug solubilized and suspended solid lipid nanoparticle formulation, respectively, when compared to the celecoxib reference. A significant difference was observed between the plasma concentration-time profiles and pharmacokinetic parameters for the three investigated formulations. Finally, this investigation displayed promising outcomes that both solubilized and suspended celecoxib in the lipid core of the solid lipid nano-particles offers the potential to improve the compound's oral bioavailability and thereby reduce the dosing frequency.
Language
English
Source (journal)
European journal of pharmaceutics and biopharmaceutics. - Stuttgart
Publication
Stuttgart : 2022
ISSN
0939-6411
DOI
10.1016/J.EJPB.2022.08.010
Volume/pages
179 (2022) , p. 1-10
ISI
000849493900001
Pubmed ID
36031014
Full text (Publisher's DOI)
Full text (open access)
Full text (publisher's version - intranet only)
UAntwerpen
Faculty/Department
Research group
Project info
Versatile X-ray powder diffraction platform for materials science.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier c:irua:190563
Creation 04.10.2022
Last edited 03.10.2024
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