Publication
Title
Beyond ferrostatin-1 : a comprehensive review of ferroptosis inhibitors
Author
Abstract
Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic radical-trapping antioxidants (RTAs) reported to block ferroptosis and it is widely used as reference compound. Ferroptosis has been linked to multiple diseases and the use of its inhibitors could have therapeutic potential. Although, novel biochemical pathways provide insights for different pharmacological targets, the use of lipophilic RTAs to block ferroptosis remains superior. In this Review, we provide a comprehensive overview of the different classes of ferroptosis inhibitors, focusing on endogenous and synthetic RTAs. A thorough analysis of their chemical, pharmacokinetic, and pharmacological properties and potential for in vivo use is provided.
Language
English
Source (journal)
Trends in pharmacological sciences. - Amsterdam
Publication
Amsterdam : 2023
ISSN
0165-6147
DOI
10.1016/J.TIPS.2023.08.012
Volume/pages
44 :12 (2023) , p. 902-916
ISI
001123742200001
Pubmed ID
37770317
Full text (Publisher's DOI)
Full text (open access)
UAntwerpen
Faculty/Department
Research group
Project info
Integrated Training in Dry Eye Disease Drug Development (IT-DED3).
Ferroptosis Inhibitors For Neurodegenerative Disorders (NeuroFerro).
Molecular mechanisms of cellular Death and Life decisions in Inflammation, Degeneration and Infection (MODEL-IDE).
Cell Death Regulation and Role in Infection and Inflammatory Diseases (CD-INFLADIS).
Investigating the role of ferroptosis in acute liver injury and multiple sclerosis with newly developed chemical tool compounds.
Design, synthesis and biological evaluation of novel ferroptosis and necroptosis inhibitors.
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 09.10.2023
Last edited 10.03.2024
To cite this reference