Publication
Title
A guide to ferroptosis, the biological rust of cellular membranes
Author
Abstract
Unprotected iron can rust due to oxygen exposure. Similarly, in our body, oxidative stress can kill cells in an iron‐dependent manner, which can give rise to devastating diseases. This type of cell death is referred to as ferroptosis. Generally, ferroptosis is defined as an iron‐catalyzed form of regulated necrosis that occurs through excessive peroxidation of polyunsaturated fatty acids within cellular membranes. This review summarizes how ferroptosis is executed by a rather primitive biochemical process, under tight regulation of lipid, iron, and redox metabolic processes. An overview is given of major classes of ferroptosis inducers and inhibitors, and how to detect ferroptosis. Finally, its detrimental role in disease is briefly discussed.
Language
English
Source (journal)
The FEBS journal. - Berlin
Publication
Berlin : 2023
ISSN
1742-464X
DOI
10.1111/FEBS.16993
Volume/pages
(2023) , p. 1-17
ISI
001107027200001
Pubmed ID
37935445
Full text (Publisher's DOI)
UAntwerpen
Faculty/Department
Research group
Project info
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Blocking ischemia reperfusion injury during dynamic preservation of organ grafts using lead ferroptosis inhibitors.
Molecular mechanisms of cellular Death and Life decisions in Inflammation, Degeneration and Infection (MODEL-IDE).
Cell Death Regulation and Role in Infection and Inflammatory Diseases (CD-INFLADIS).
Publication type
Subject
Affiliation
Publications with a UAntwerp address
External links
Web of Science
Record
Identifier
Creation 28.11.2023
Last edited 10.01.2024
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